Thiol-quinone methide

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August undefined, 2024

WebJan 1, 2014 · National Center for Biotechnology Information WebNov 1, 2024 · The thermoresponsive quinone methide-thiol dynamic reaction was employed to prepare thermadapt shape memory polymer. • The thermal-induced dynamic reaction endowed cross-linked PCL with solid-state plasticity under high temperature. • The cross-linked PCL networks behaved great elasticity-based shape memory performance and …

Thermoresponsive self-healable and recyclable polymer …

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebMay 1, 1990 · This article is cited by 31 publications. Fabian Göricke, Stefan Haseloff, Michael Laue, Maximilian Schneider, Thomas Brumme, Christoph Schneider. Phosphoric Acid Catalyzed Formation of Hydrogen-Bonded o-Quinone Methides. hertz harrisburg car insurance info

Quinone methide - Wikipedia

WebNov 28, 1997 · Quinone methides with significantly different structures, however, such as o-quinone methides or quinone methides with extended conjugation, may react with different selectivities. For example, it was reported that the quinone methide from eugenol binds more readily to the ε -amino than the α -amino group of lysine [32] . WebNov 28, 1997 · The quinone methides were prepared by adding 5 g of lead dioxide to 200 mg of each phenol dissolved in 200 ml of pentane and stirring for 30 min at 25°C [6]. This … maynard\u0027s restaurant flowery branch ga

Thermadapt shape memory polymers based on thermally

WebMay 8, 2012 · These reactions, including thiol-quinone methide, [81] disulfide exchange, [82,83] thiol-disulfide interconversion, [84] diselenide exchange, [85] and … WebThese results suggest that eugenol mediates its hepatotoxic effects primarily through depletion of cytoprotective thiols and interference in thiol-dependent processes such as GJIC. Furthermore, our results support the hypothesis that the toxic effects of eugenol are mediated through its quinone methide metabolite. hertz harlingen tx airportWebA novel thermoresponsive dynamic covalent chemistry was developed based on 1,6-conjugate addition between a stable para-quinone methide, namely 2,6-di-t-butyl-7-phenyl-p-quinone methide (pQM), and thiol nucleophiles.When applying it in the formation of polymer networks, covalently cross-linked polymer bulk materials were developed with … maynard\\u0027s towing columbus ohio

"WebApr 12, 2024 · A plausible rationale for isoeugenol's strong skin sensitization is proposed based on the formation of a hydroxy quinone methide as a reactive intermediate rather than the previously assumed ... " - Thiol-quinone methide

Thiol-quinone methide

US09580553B2 Thermally-activated self-immolative materials

WebReconfigurable Surfaces Based on Thiol-Quinone Methide Photoclick Reaction. Photoclick reactions of thiol-ene/yne in surface modification have been studied extensively. 55, 54, … WebA polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment.

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WebNov 28, 1997 · Quinone methides with significantly different structures, however, such as o-quinone methides or quinone methides with extended conjugation, may react with … WebAug 22, 2016 · Ferrociphenols (FCs) and their oxidized, electrophilic quinone methide metabolites (FC-QMs) are organometallic compounds related to tamoxifen that exhibit strong antiproliferative properties. To evaluate the reactivity of FC-QMs toward cellular nucleophiles, we studied their reaction with selected thiols.

WebThe parent p-quinone methide 1 and its relatives that contain the quinone methide functionality have long attracted the interest of discerning chemists. 1 can be thought of as a ... parameter βnuc = 0.11 for addition of strongly nucleophilic thiol anions to the weak electrophile 2, ... WebNov 27, 1996 · 4-Alkylphenols, such as the antioxidant 2,6-di-tert-butyl-4-methylphenol (BHT), exhibit toxicities that appear to be mediated by their oxidative metabolism to electrophilic quinone methides. Reactions of these Michael acceptors with simple nucleophiles and proteins have been reported, but little information is available on quinone methide binding …

WebJan 1, 2011 · Quinone methides are highly reactive and this reflects the large contribution of the polar zwitterion to the overall molecular structure (Scheme 1).In other words, the 1,4 … WebThe parent p-quinone methide 1 and its relatives that contain the quinone methide functionality have long attracted the interest of discerning chemists. 1 can be thought of …

WebResults of the present study demonstrate that as a thiol-scavenging agent for this reaction Cys is preferred over GSH and N-acetylcysteine. ... GSH. Thus, the results of the present study indicate that in biological systems covalent addition of quercetin quinone methide to tissue protein sulfhydryl groups can be expected. The transient nature ...

WebNucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones. Organic Letters 2024, 19 (8) , ... Radical-scavenging Activity of the Reaction Products of Isoeugenol with Thiol, Thiophenol, Mercaptothiazoline or Mercaptomethylimidazole Using the Induction Period Method. Molecules 2007, 12 (8) ... hertz harrisburg international airportWebArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. maynard\u0027s tree serviceWebJan 1, 2011 · Quinone methides are highly reactive and this reflects the large contribution of the polar zwitterion to the overall molecular structure (Scheme 1).In other words, the 1,4-quinone methide is a benzylic carbocation that is strongly stabilized by the resonance electron-donating 4-O − substituent. 3 Consequently, the rate constants k Nu for addition … maynard\u0027s tawny port 10 year oldWebThe photo-dehydration (3-hydroxynaphthalen-2-yl)(4-hydroxyphenyl)methanol (QMP 1 for quinone methide precursor) can produce both tautomers: o-naphthoquinone methide (oNQM 1) and p-quinone methide ... maynard\\u0027s silverdale washingtonWebAug 22, 2016 · Ferrociphenols (FCs) and their oxidized, electrophilic quinone methide metabolites (FC-QMs) are organometallic compounds related to tamoxifen that exhibit … hertz harry reid internationalWebJun 24, 2016 · Alkylation of duplex DNA with a triplex-forming conjugate alternatively containing a quinone methide precursor (QMP1) and a QM self-adduct. The chemical competence for alkylation of duplex DNA by ... hertz harry reid airportWebOct 6, 1992 · The results will provide some information as to the relative thermodynamic stability of thiol-quinone methide and nudeoside-quinonmethide adducts at different pH's. Given the small amounts of quinone methide 1a seen at pH 7, it might seem unreasonable to expect a nucleoside to be exchange for a thiol. The results were quite surprising. hertz harrisburg car insurance